Friedrich Brunner Selected Research

PD 155080

1/2004	Effect of endothelin antagonism on contractility, intracellular calcium regulation and calcium regulatory protein expression in right ventricular hypertrophy of the rat.
2/2002	Defective intracellular calcium handling in monocrotaline-induced right ventricular hypertrophy: protective effect of long-term endothelin-A receptor blockade with 2-benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl-)- 4-oxobut-2-enoate-sodium (PD 155080).

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Friedrich Brunner Research Topics

Disease

3	Pulmonary Hypertension 08/2008 - 02/2002
3	Reperfusion Injury 11/2006 - 01/2003
2	Myocardial Ischemia (Ischemic Heart Diseases) 11/2006 - 01/2003
2	Ischemia 11/2006 - 05/2002
2	Right Ventricular Hypertrophy 01/2004 - 02/2002
2	Hypertrophy 01/2004 - 02/2002
2	Cardiovascular Diseases (Cardiovascular Disease) 05/2002 - 04/2002
1	Cardiotoxicity 07/2009
1	Endotoxemia 08/2008
1	Proteinuria 07/2006
1	Diabetic Cardiomyopathies 07/2006
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2006
1	Acidosis 01/2005
1	Fibrosis (Cirrhosis) 01/2004
1	Heart Failure 01/2004
1	Ventricular Remodeling 01/2004
1	Cardiomyopathies (Cardiomyopathy) 02/2003
1	Atherosclerosis 05/2002
1	Cardiomegaly (Heart Hypertrophy) 02/2002

Drug/Important Bio-Agent (IBA)

4	Nitric Oxide Synthase (NO Synthase)IBA 07/2009 - 05/2002
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2009 - 01/2003
3	Endothelins (Endothelin)IBA 08/2008 - 02/2002
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2006 - 04/2002
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2006 - 01/2003
2	Oxidants (Oxidizing Agents)IBA 07/2006 - 04/2002
2	MonocrotalineIBA 01/2004 - 02/2002
2	CalciumIBA 01/2004 - 02/2002
2	PD 155080IBA 01/2004 - 02/2002
2	Endothelin A ReceptorIBA 01/2004 - 02/2002
2	Oxygen (Dioxygen)IBA 05/2002 - 04/2002
1	AnthracyclinesIBA 07/2009
1	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2009
1	IsoenzymesIBA 07/2009
1	MitogensIBA 08/2008
1	sorbinilIBA 08/2008
1	Aldehyde Reductase (Aldose Reductase)IBA 08/2008
1	EndotoxinsIBA 08/2008
1	Vasoconstrictor AgentsIBA 08/2008
1	Endothelin-1 (Endothelin 1)IBA 08/2008
1	zopolrestatIBA 08/2008
1	BradykininIBA 11/2006
1	Blood Glucose (Blood Sugar)IBA 11/2006
1	Streptozocin (Streptozotocin)FDA Link 11/2006
1	CatalaseIBA 07/2006
1	AtrasentanIBA 07/2006
1	CreatinineIBA 07/2006
1	Adrenergic Agents (Adrenergic Drugs)IBA 07/2006
1	Epinephrine (Adrenaline)FDA LinkGeneric 01/2005
1	Simendan (Levosimendan)IBA 01/2005
1	AequorinIBA 01/2004
1	phospholambanIBA 01/2004
1	Hydroxyproline (4 Hydroxyproline)IBA 01/2004
1	Proteins (Proteins, Gene)FDA Link 01/2004
1	Endothelin Receptors (Endothelin Receptor)IBA 01/2004
1	PPAR alphaIBA 02/2003
1	Arginine (L-Arginine)FDA Link 05/2002
1	Free RadicalsIBA 04/2002
1	SodiumIBA 02/2002

Therapy/Procedure

1	Intraperitoneal Injections 02/2002